dept of biochemistry and molecular biophysics




Faculty

picture of bill frazier
William A. Frazier
 Professor of Biochemistry and Molecular Biophysics
Dept. of Biochemistry and
Molecular Biophysics

Office: 1902 South Building
Phone: 314-362-3348
Fax: 314-362-7183
Email: frazier@biochem.wustl.edu

Lab Website
Research Opportunities

Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110

Research Interests

Structure-function analysis along with in vitro and in vivo models of vascular disease are employed to understand how thrombospondin-1 and its receptor CD47 control nitric oxide signaling in vascular cells.



Selected Publications

  • Isenberg, J.S. Annis, D.S., Pendrak, M.L., Ptaszynska, M., Frazier, W.A., Mosher, D.F. and Roberts, D.D. Differential interactions of thrombospondins-1, -2 and -4 with CD47 and effects on cGMP signaling and ischemic injury responses. J Biol Chem (E-pub ahead of print.) (2008).

  • Isenberg, J.S. Maxhimer, J.B., Powers, P., Tsokos, M., Frazier, W.A. and Robert, D.D. Treatment of liver ischemia–reperfusion injury by limiting thrombospondin-1/CD47 signaling. Surgery 144:752-761 (2008).

  • Isenberg, J.S., Frazier, W.A., Krishna, M.C., Wink, D.A. and Roberts, D.D. Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling. Curr Drug Targets 9:833-841 (2008).

  • Vomund, A.N., Stuhlsatz-Krouper, S., Dimitry, J., Song, Y. and Frazier, W.A. A naturally occurring extracellular alpha-beta clasp contributes to stabilization of beta3 Integrins in a bent, resting conformation. Biochemistry 47:11616-11624 (2008).

  • Isenberg, J.S., Romeo, M.J., Maxhimer, J.B., Smedley, J., Frazier, W.A. and Roberts, D.D. Gene silencing of CD47 and antibody ligation of Thrombospondin-1 enhance ischemic tissue survival in a porcine model: Implications for human disease. Ann Surg. 247:860-868 (2008).

  • Isenberg, J.S., Romeo, M.J, Yu, C., Yu, C.K., Nghiem, K., Monsale, J., Rick, M.E., Wink, D.A., Frazier, W.A. and Roberts, D.D. Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Blood 111:613-623 (2008).

  • Isenberg, J.S., Roberts, D.D. and Frazier, W.A. CD47. A new target in cardiovascular therapy. Arterioscler Thromb Vasc Biol. 28:615-621 (2008).

  • Isenberg, J.S., Pappan, L.K., Romeo, M.J., Abu-Asab, M., Tsokos, M., Wink, D.A., Frazier, W.A. and Roberts, D.D. Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts. Ann Surg. 247:180-190 (2008).

 

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