Garland Marshall Professor Dept. of Biochemistry and Molecular Biophysics

Research Interests

Major focus is molecular recognition - the basis of intermolecular interactions and specificity seen in drug and hormone receptors, antigen-antibody and substrate-enzyme systems.

Selected Publications

• Oprea, T.I., Bologa, C.G., Boyer, S., Curpan, R.F., Glen, R.C., Hopkins, A.L., Lipinski, C.A., Marshall, G.R., Martin, Y.C., Ostopovici-Halip, L., Rishton, G., Ursu, O., Vaz, R.J., Waller, C., Waldmann, H. and Sklar, L.A. A Crowdsourcing evaluation of the NIH chemical probes. Nat Chem Biol 5:441-447 (2009).

• Arbor, S. and Marshall, G.R. A virtual library of constrained cyclic tetrapeptides that mimics all four side-chain orientations for over half the reverse turns in the protein data bank. J Comput Aided Mol Des. 23:87-95 (2009).

• Taylor, C.M., Barda, Y., Kisselev, O.G. and Marshall, G.R. Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem51:5297-5303 (2008).

• Nikiforovich, G.V., Marshall, G.R. and Baranski, T.J. Modeling molecular mechanisms of binding of the anaphylatoxin C5a to the C5a receptor. Biochemistry 47:3117-3130 (2008).

• Cegelski, L, Marshall, G.R., Eldridge, G.R. and Hultgren, S.J. The biology and future prospects of antivirulence therapies. Nature Rev Microbiol. 6:17-27 (2008).

• Che, Y. and Marshall, G.R. Privileged scaffolds targeting reverse-turn and helix recognition. Expert Opin Ther Targets 12:101-114 (2008).

• Ye, Y., Liu, M., Kao, J.L. and Marshall, G.R. Design, synthesis, and metal binding of novel pseudo-oligopeptides containing two phosphinic acid groups. Biopolymers 89:72-85 (2008).

• Berg-Cross, S., Kao, J., Wu, Y. and Marshall, G.R. c[D-pro-Pro-D-pro-N-Methyl-Ala] Adopts a rigid conformation that serves as a scaffold to mimic reverse-turn. Biopolymers 90:384-393 (2008).

• Marshall, G.R., Feng, J.A. and Kuster, D.J. Back to the future: Ribonuclease A. Biopolymers 90:259-277 (2008).