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Tom Ellenberger
Wittcoff Professor and Head
Dept. of Biochemistry and
Molecular Biophysics |
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Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110
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Research
Research in the Ellenberger laboratory focuses on the molecular structures and cellular functions of proteins that replicate DNA, repair chemical damage, and regulate chromatin structure. These enzymes and regulatory proteins ensure the faithful transmission of our genetic blueprint to future generations.
Selected Publications
- Etzion, Y., Hackett, A., Proctor, B.M., Ren, J., Nolan, B., Ellenberger, T. and Muslin, A.J. An unbiased chemical biology screen identifies agents that modulate uptake of oxidized LDL by macrophages. Circ Res (E-pub ahead of print.) (2009).
- Song, W., Pascal, J.M. and Ellenberger, T. and Tomkinson, A.E. The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps. DNA Repair (E-pub ahead of print.) (2009).
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Raschle, M., Knipsheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J.D., Ellenberger, T.E., Scharer, O.D. and Walter, J.C. Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134:969-980. (2008).
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Zhong, S., Chen, X., Zhu, X., Dziegielewska, B., Bachman, K.E., Ellenberger, T., Ballin, J.D., Wilson, G.M., Tomkinson, A.E. and MacKerell, Jr., A.D. Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem 51:4553-4562 (2008).
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Ellenberger, T. and Tomkinson, A.E. Eukaryotic DNA ligases: Structural and functional insights. Annu Rev Biochem 77:313-338 (2008).
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Chen, X., Zhong, S., Zhu, X., Dziegielewska, B., Ellenberger, T., Wilson, G.M., MacKerell, A.D. Jr and Tomkinson, A.E. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68:3169-3177 (2008).
