dept of biochemistry and molecular biophysics




Faculty

picture of Tom Ellenberger
Tom Ellenberger
 Wittcoff Professor and Head
Dept. of Biochemistry and
Molecular Biophysics

Office: 2901 South Building
Phone: 314-362-0287
Fax: 314-362-4432
Email: tome@biochem.wustl.edu

Lab Website
Research Opportunities

Mailing Address:
WUSM - Biochemistry Dept.
660 S. Euclid Ave., MS8231
St. Louis, MO 63110

Research Interests

Nucleic enzymology, structural biology, macromolecular interactions and molecular recognition



Selected Publications


  • Raschle, M., Knipsheer, P., Enoiu, M., Angelov, T., Sun, J., Griffith, J.D., Ellenberger, T.E., Scharer, O.D. and Walter, J.C. Mechanism of replication-coupled DNA interstrand crosslink repair. Cell 134:969-980. (2008).

  • Zhong, S., Chen, X., Zhu, X., Dziegielewska, B., Bachman, K.E., Ellenberger, T., Ballin, J.D., Wilson, G.M., Tomkinson, A.E. and MacKerell, Jr., A.D. Identification and validation of human DNA ligase inhibitors using computer-aided drug design. J Med Chem 51:4553-4562 (2008).

  • Ellenberger, T. and Tomkinson, A.E. Eukaryotic DNA ligases: Structural and functional insights. Annu Rev Biochem 77:313-338 (2008).

  • Chen, X., Zhong, S., Zhu, X., Dziegielewska, B., Ellenberger, T., Wilson, G.M., MacKerell, A.D. Jr and Tomkinson, A.E. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68:3169-3177 (2008).

  • Cotner-Gohara, E., Kim, I.K., Tomkinson, A.E. and Ellenberger, T. Two DNA binding and nick recognition modules in human DNA ligase III. J. Biol. Chem. 283:10764-10772 (2008).

  • Tsodikov, O.V., Ivanov, D., Orelli, B., Staresincic, L, Shoshani, I., Oberman, R., Scharer, O.D., Wagner, G. and Ellenberger, T. Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA. EMBO J. 26:4768-4776 (2007).

  • Aihara, H., Huang, W.M. and Ellenberger, T. An interlocked dimer of the Protelomerase TelK Distorts DNA Structure for the Formation of Hairpin Telemeres. Mol Cell. 27:901-913 (2007).

  • Ivanov, D., Tsodikov, O.V., Kasanov, J., Ellenberger, T., Wagner, G. and Colins, T. Domain-swapped dimerization of the HIV-1 capsid C-terminal domain. Proc Natl Acad Sci USA 104:4353-4358. (2007).

 

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