Research Interests

Solution and solid-state NMR spectroscopy: dynamics of integral membrane proteins, functional importance of protein dynamics, mechanism of transporter proteins, protein-lipid interaction

Selected Publications

• Ramamoorthy, A., Lee, D-K., Santos, J.S. and Henzler-Wildman, K.A. Nitrogen-14 Solid-state NMR spectroscopy of aligned phospholipid bilayers to probe peptide-lipid interaction and oligomerization of membrane associated peptides. J. Am. Chem. Soc. 130:11023–11029 (2008).

• Porcelli, F., Verardi, R., Shi, L., Henzler-Wildman, K.A., Ramamoorthy, A., and Veglia, G. NMR Structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles. Biochemistry, 47:5565–5572 (2008).

• Henzler-Wildman K.A. and Kern D. Dynamic personalities of proteins. Nature 450:964-972 (2007).

• Henzler-Wildman K.A., Lei M., Thai V., Kerns S.J., Karplus M., and Kern D. A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature 450:913-916 (2007).

• Henzler-Wildman K.A., Thai V., Lei M., Ott M., Wolf-Watz M., Fenn T., Pozharski E., Wilson M.A., Petsko G.A., Karplus M., Hübner C.G., and Kern, D. Intrinsic motions along an enzymatic reaction trajectory. Nature 450:838-844 (2007).

• Wolf-Watz M, Thai V, Henzler-Wildman K, Hadjipavlou G, Eisenmesser EZ, Kern D. Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair. Nat. Struct. Mol. Biol. 11:945-949 (2004).

• Henzler-Wildman K.A., Martinez G.V., Brown M.F., Ramamoorthy A. Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37. Biochemistry 43:8459-8469 (2004).